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Mezcal Grapefruit Cocktail

The smoky-sweet flavor combination of this Mezcal Grapefruit cocktail is wonderful for a refreshing change.

Mezcal Grapefruit Cocktail

We’ve been making all kinds of cocktails around here lately. That’s not a new thing, but with the Super Bowl having just passed in addition to my recent trip to Orange Beach, AL (so fun!), I’ve had more opportunities than normal for some fun cocktail creation. Mezcal Grapefruit cocktails are always a hit.

My newest obsession is mezcal so I knew I’d be taking advantage of its smoky flavor. I also had a bag of fresh ruby red grapefruit – which goes so well with mezcal – and I wanted to use a few of those, too.

Fresh grapefruit juice is so much better than bottled so I always take the extra step to juice a few for all our cocktails. And I always keep a little citrus soda on hand since it’s perfect to top off any number of cocktails.

I’ll often mix it with vodka and a little fresh juice; I love the sweetness it adds as well as the bit of carbonation.

Mezcal Grapefruit Cocktail

As I’ve talked about many, many times, I love having friends over and putting a “help yourself bar” out so people can not only make drinks for themselves but also get creative! I usually put out vodka, gin, tequila, and mezcal (sometimes a bottle of rum if I have it).

Definitely some citrus soda (such as Sprite or 7up, tonic water, seltzer, loads of limes and a few lemons, bitters, a few juices (always squeeze them fresh!) as well as some beer and wine. And you know me – the spice fiend – which means there are always some fresh peppers to drop in, too.

Mezcal Grapefruit Cocktail

This Mezcal Grapefruit cocktail has a shot of mezcal, a little fresh grapefruit juice and some citrus soda to top it off. A little a squeeze of lime brings it all together, plus I like to add a slice of jalapeno for a tiny bit of spice. Add more or less lime, juice or soda according to taste. 

Mezcal & Grapefruit Cocktail

Mezcal & Grapefruit Cocktail

Yield: 1
Prep Time: 10 minutes
Total Time: 10 minutes


  • 2 ounces Mezcal
  • 4 ounces fresh grapefruit juice
  • 2 ounces citrus soda
  • 1 lime wedge, plus an extra for rim, if desired
  • 1 jalapeno slice, optional
  • Salt for rim, mix it with a little ancho chile powder, if desired


  1. Run the side of the lime wedge along half the side of a highball glass at the very top (see picture). Press into salt until it adheres to the glass.
  2. Fill glass with ice. Add mezcal, grapefruit juice and soda to glass. Squeeze in the juice of the lime wedge and drop in jalapeno slice, if desired.
Kristy Bernardo
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Saturday 23rd of February 2019

This is such a great recipe! I love it. A plus that I had every ingredient in the house already! Thanks!

Lauren Geruso

Monday 28th of January 2019

I love mezcal! I can’t wait to give this a go! I may try to spice up the tequila before mixing, maybe soak it in some jalapeñ I cannot wait!

Thanks for this recipe

Mark Fletcher

Friday 18th of May 2018

I recently received a bottle of Mezcal, & I’ve held on to it, because I don’t know of its taste, so thank you for your drink recipes/recommendation.

What vegetarian dish would you recommend to have with this drink ?


Friday 19th of January 2018

So you're going to take the time to squeeze fresh juice and then top with garbage HFCS-laden soda? Get it together. Shake the mezcal and grapefruit with some agave simple syrup (1 to 1 ) and maybe some Peychaud's Bitters in a shaker with ice, strain into an ice-filled glass and top with club soda. Maybe muddle the jalapeno if using before shaking to add some spice.


Friday 26th of November 2021

@JJ, oh you're going to use a sellout pepper like jalapeno? why not use some Carolina reapers instead? your post was rude.

Kristy Bernardo

Friday 19th of January 2018

Gosh, what a sweet comment. I just love hearing from kind people. Thank you, JJ!

Mary France

Thursday 13th of April 2017

Yess! I am so ready for all the summery drinks. I am not the biggest spicy fan but I would give this a go!

Kristy Bernardo

Friday 19th of May 2017

Thanks, Mary!

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